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Jun 22 primary breast lymphoma ( PBL) has been arbitrarily defined as disease localized to one , both breasts with , · The breast is a rare extranodal site of non- Hodgkin lymphoma without regional lymph nodes involvement. May 21, · Most previous studies of the CpG island methylator phenotype ( CIMP) in colorectal cancer ( CRC) have been conducted on a relatively small numbers of CpG sites.